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Symbol
Name
ID 		Cr2
complement receptor 2
MGI:88489
Phenotype annotations related to hematopoietic system
Darker colors indicate more annotations
Human Phenotypes
Decreased circulating IgA level
Chronic partially decreased circulating IgG1
Chronic (near) absent circulating IgG4
Decreased circulating total IgG
Reduced isohemagglutinin level
Decreased specific pneumococcal antibody level
Hemolytic anemia
Leukopenia
Thrombocytopenia
Splenomegaly
Disease(s) Associated with CR2
common variable immunodeficiency 7
systemic lupus erythematosus

Mouse Phenotypes
abnormal class switch recombination
abnormal memory B cell differentiation
decreased neutrophil cell number
decreased B-1a cell number
decreased follicular B cell number
increased marginal zone B cell number
decreased B cell number
abnormal B-1 B cell morphology
abnormal spleen germinal center morphology
decreased spleen germinal center number
decreased spleen germinal center size
abnormal B cell physiology
abnormal B cell activation
abnormal germinal center B cell physiology
decreased IgG1 level
decreased IgG2a level
decreased IgG2b level
decreased IgG2c level
decreased IgG3 level
decreased IgG level
decreased IgM level
increased IgM level
decreased immunoglobulin level
Availability Mouse Genotype
Cr2M1Btlr/Cr2M1Btlr
Cr2tm1.1Jhws/Cr2tm1.1Jhws
Cr2tm1Crr/Cr2tm1Crr
Cr2tm1Hmo/Cr2tm1Hmo
Cr2tm1Tft/Cr2tm1Tft
Cr2tm2.1(HLA-A)Crr/Cr2tm2.1(HLA-A)Crr
Cr2tm2.1Jhws/Cr2tm2.1Jhws
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory